1. The eyes of an emoticon, typically → COLON
2. Make a case (for) → ARGUE
3. Opposite of credit → DEBIT
4. "And ___ bed" → SOTO
5. Nothing → NIL
6. Dr. Seuss' "And to Think That ___ It on Mulberry Street" → ISAW
7. 4 on a par 3, e.g. → BOGEY
8. Hard-to-clean-up sparkly stuff → GLITTER
9. Like good omens → AUSPICIOUS
10. College instructor, for short → PROF
11. "To thine own ___ be true" → SELF
13. Sudden, powerful gust of wind → SQUALL
16. Used a stool, say → SAT
18. Athleisure brand originally from Italy → FILA
22. Homes on branches → NESTS
25. ___ Day (April observance) → ARBOR
27. Climactic fight in a video game → BOSSBATTLE
28. 0% filled → EMPTY
30. Fun word to shout into a canyon → ECHO
31. Fashion inits. in Manhattan → DKNY
32. Those, en español → ESOS
33. Puts on, as a jacket → DONS
34. Yokel → RUBE
35. Apex predator of the ocean → ORCA
37. Marks, as a ballot square → XESIN
39. "The Thinker" sculptor → RODIN
42. Pored over → PERUSED
43. Not act up → BEHAVE
46. ___ Sea (arm of the Arctic Ocean) → KARA
48. Making a plate appearance → ATBAT
50. Scientist Hubble with a telescope named after him → EDWIN
51. Fuzzy-feeling leather → SUEDE
52. Extremes of the earth → POLES
53. Nightwear, informally → PJS
54. Oblong tomato type → ROMA
55. Lose traction → SLIP
56. "OK, go ahead" → SURE
58. Casual collared shirt → POLO
61. Desire → YEN