1. Spider's creation → WEB
2. Peace promoter Yoko → ONO
3. Cell's messenger material → RNA
4. Istanbul native → TURK
5. Conceal → HIDE
6. Lacking a key, in music → ATONAL
7. Crazy Horse's people → SIOUX
8. Adjustable skirt feature → HEM
9. Port-au-Prince's country → HAITI
10. Get there → ARRIVE
11. Looked lasciviously → LEERED
12. Commands → ORDERS
15. Police officer who monitors an assigned area → PATROLMAN
17. Label as G or R, say → RATE
20. Spicy marinade with chili peppers → ADOBO
21. Exam for a doctor-to-be → MCAT
22. Parks honored in the Capitol's Statuary Hall → ROSA
23. Walrus's long tooth → TUSK
25. Composer Stravinsky → IGOR
27. Have to have → NEED
28. Passengers getting an illicit free ride → STOWAWAYS
32. Org. for Patriot games → NFL
33. Actor McGregor with a Golden Globe for "Fargo" → EWAN
35. Pertaining to development in the womb → FETAL
36. Off-key, in a way → FLAT
37. Like some history or hygiene → ORAL
38. City surrounding Vatican City → ROME
39. On bended ___ → KNEE
42. Overly refined → EFFETE
43. "Yikes!," to a Brit → BLIMEY
44. Reporter's attribution atop an article → BYLINE
46. Read → PERUSE
47. Rock's Carmen or Clapton → ERIC
49. Earthy deposits by a river → SILTS
50. Steak similar to a porterhouse → TBONE
54. Stylish → CHIC
55. Margin → EDGE
57. "___ better to have loved and lost ..." → TIS
58. Passé → OLD
59. Misfortune → WOE
60. Agree silently → NOD