1. Circadian dysrhythmia, less fancily → JETLAG
2. By the item → APIECE
3. Enjoy a home-cooked meal, say → DINEIN
4. "Oh no!," in comics → ACK
5. Certain possessive pronoun → HERS
6. With all judges present → ENBANC
7. Grilled cornmeal cake → AREPA
8. "haha" → LOL
9. "Black Jeopardy!" show, in brief → SNL
10. Nobel, for one → AWARD
11. Bold accessory for a suit → POWERTIE
12. Sincere → EARNEST
13. Back off (from) → SHYAWAY
18. Day for hunting → EASTER
22. "The Bear" actress Edebiri → AYO
24. Clear up, as a windshield → DEFOG
26. Snoopy → NOSY
27. Savory rice porridge → CONGEE
29. Words of concurrence → IDOTOO
33. "___ 'nuff!" → SHO
34. Almost there → CLOSE
35. Cynophilist → DOGLOVER
36. Purple boba choice → TARO
37. Travel option that serves 46 states → AMTRAK
38. Secrecy → STEALTH
39. Virus of sorts → MALWARE
43. Chain email abbr. → FWD
44. Biblical collection of 150 poems → PSALMS
45. Kitchen grinder → PESTLE
46. Kutcher of "That '70s Show" → ASHTON
47. "Later" → SEEYOU
49. Clear, as a whiteboard → ERASE
50. Equivalent of a 1.3 G.P.A., say → DPLUS
54. Small bouquet → POSY
57. Hawaiian pizza topping → HAM
58. Lilly of pharmaceuticals → ELI
59. Dr. Seuss's Sam-___ → IAM