1. Bolt → ABSCOND
2. Certain Windows hard drive malfunction → IOERROR
3. *Conspicuous → NOTABLE
4. Stupid stuff it's fun to know → TRIVIA
5. Level-ending foe → BOSS
6. Educated guess: Abbr. → EST
7. Sgt., e.g. → NCO
8. Like lemon curd → TANGY
9. Preceder of "Bites" and "Bars" in commercial names → OREO
10. *Chance to meet one-on-one with a professor → OFFHOURS
11. "Copy me" → DOASIDO
12. Runner Down Under → EMU
13. Certain heir → SON
18. Make in the end → NET
22. Steady humming sounds → THRUMS
24. Locale for catfish or carp → POND
25. What allows Neo to disconnect from the Matrix → REDPILL
27. Spanish 101 verb → SER
28. Whom you might greet with open arms, for short? → TSA
30. Novelist Charles who wrote "The Cloister and the Hearth" → READE
31. Prefix with botanist → PALEO
33. "Sure … if you say so" → WELLOK
35. Enjoys oneself uninhibitedly … or a punny title for this puzzle → ROCKSOUT
36. Profess → AVER
37. Something Lincoln once led, for short → GOP
38. Italian time unit → ORA
39. Card game with a winning score of 5,000 points → CANASTA
41. *Book addenda → APPENDS
42. Chicken ___ → MARSALA
43. Thrive → PROSPER
46. Narrow channel → STRAIT
48. Derisive look → SNEER
49. OB/GYN offering → IUD
51. Crisply shown, as on TV → INHD
52. Wooded valley → DELL
53. Coop → PEN
54. Performed amazingly, in slang → ATE
56. Id's counterpart → EGO
57. The First State: Abbr. → DEL