1. Spots for cozy dates → CAFES
6. Slope → RISE
10. What A's and B's are good for → GPA
13. Person with terrible manners → BRUTE
14. Broadway great Menzel → IDINA
16. Nickname that's an alternative to Cam → RON
17. Some basic guidelines [2, Spanish] → DOSANDDONTS
19. Nonprofit's domain name ender → ORG
20. Paris agreement → OUI
21. Take to court → SUE
22. Act smart → GETCUTE
24. Molecule with a non-unique formula → ISOMER
26. Fluorescent gemstone [4, Danish and Norwegian] → FIREOPAL
27. "Girls" creator Dunham → LENA
28. Slightly → ABIT
30. Some parallel bars → RAILS
31. Agrees (with) → JIBES
33. Rarely visited places on earth → POLES
34. Climactic baseball event … or what the starts of 17-, 26-, 44- and 52-Across form? → WORLDSERIES
36. "Breaking Bad" sister-in-law → MARIE
37. Touches and Shuffles → IPODS
38. Black prom rentals → SUITS
39. Bubbly bar → SOAP
40. Idiomatic sticking point → CRAW
44. Chemist who co-discovered 26-Down [8, Italian] → OTTOHAHN
46. It's controlled in meditation → BREATH
48. Food spread popular in England → MARMITE
49. Levi's competitor → LEE
50. Toilet paper thickness → PLY
51. ___ out of house and home → ATE
52. Carpe diem [16, French] → SEIZETHEDAY
55. Picasso's "___ Demoiselles d'Avignon" → LES
56. A little under half of humanity → MALES
57. Entertain → AMUSE
58. Establishes what is, informally → IDS
59. ___ best friend → MANS
60. Sidekick of Dora the Explorer → BOOTS